Drug Target ID, Ltd.
6525 EC, Nijmegen,
These studies include candidate gene association studies, genome-wide association studies (GWASs) and (genome-wide) sequencing studies, copy number variation (CNV) studies, mRNA/protein expression studies, and studies on (genetic) animal models. Thus far, we have successfully applied our approach to the neurodevelopmental disorders dyslexia, attention deficit hyperactivity disorder (ADHD), motor coordination problems, autism spectrum disorders (ASDs) and obsessive-compulsive disorder (OCD).
We have also applied/are currently applying the same approach to several other complex genetic disorders, including additional neuropsychiatric and neurological disorders, such as schizophrenia, bipolar disorder, Parkinson’s disease, Alzheimer’s disease, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and myotonic dystrophy. Moreover, we have applied our approach to complex non-neurological disorders, such as congenital anomalies of the kidney and urinary tract (CAKUT) and cleft lip/palate (CL/P).
Recently, we have also started building molecular landscapes for acute lymphatic leukemia and breast cancer, in collaboration with the Radboud University Medical Center. In addition, we have ongoing research collaborations with Harvard Medical School (USA) and the universities of Cambridge (UK) and Leuven (Belgium).